Any feedback?
Literature summary for 1.3.1.98 extracted from
- Molecular docking and dynamic simulation of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) obtained from Mycobacterium tuberculosis using in silico approach (2021), Netw. Model. Anal. Health Inform. Bioinform., 10, 40 .
No PubMed abstract available
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| enzyme bound to FAD and K+, hanging drop vapor diffusion method | Mycobacterium tuberculosis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ZINC11839554 | - |
Mycobacterium tuberculosis | |
| ZINC12242812 | - |
Mycobacterium tuberculosis | |
| ZINC14976552 | - |
Mycobacterium tuberculosis | |
| ZINC14982226 | - |
Mycobacterium tuberculosis | |
| ZINC14995379 | - |
Mycobacterium tuberculosis | |
| ZINC18122756 | - |
Mycobacterium tuberculosis |  |
| ZINC19837204 | - |
Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetylenolpyruvylglucosamine + NADPH + H+ | Mycobacterium tuberculosis | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? | |
| UDP-N-acetylenolpyruvylglucosamine + NADPH + H+ | Mycobacterium tuberculosis H37Rv | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WJL9 | - |
- |
| Mycobacterium tuberculosis H37Rv | P9WJL9 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetylenolpyruvylglucosamine + NADPH + H+ | - |
Mycobacterium tuberculosis | UDP-N-acetylmuramic acid + NADP+ | - |
? | |
| UDP-N-acetylenolpyruvylglucosamine + NADPH + H+ | - |
Mycobacterium tuberculosis H37Rv | UDP-N-acetylmuramic acid + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MurB | - |
Mycobacterium tuberculosis |
| UDP-N-acetylenolpyruvoylglucosamine reductase | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Mycobacterium tuberculosis | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00000226 | - |
ZINC19837204 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00000389 | - |
ZINC11839554 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00001281 | - |
ZINC14976552 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.0000132 | - |
ZINC18122756 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00001336 | - |
ZINC14995379 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00001453 | - |
ZINC14982226 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00002277 | - |
ZINC12242812 | pH and temperature not specified in the publication | Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme catalyzes the final steps of the UDP-N-acetylmuramic acid formation in the peptidoglycan biosynthesis pathway | Mycobacterium tuberculosis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
